Selank / NA-Selank / NA-Selank-Amidate Testing
Heptapeptide based on tuftsin; Russian-developed anxiolytic research peptide. Available as plain, N-acetyl, and amidated variants.
Mechanism of action
Synthetic heptapeptide based on the immunomodulator tuftsin, with an added Pro-Gly-Pro stabilization motif. Anxiolytic effects studied in Russian clinical practice; mechanisms include GABA modulation, BDNF expression, and tuftsin-receptor signaling on macrophages.
Sequence & structure
Three different commercial variants: plain Selank, N-acetyl Selank, and N-acetyl-amidate Selank. Vials are very frequently mis-labeled between variants.
Research areas
- ●Generalized anxiety (approved in Russia as nasal spray)
- ●Stress and cognitive performance
- ●Immune modulation
What we test on Selank / NA-Selank / NA-Selank-Amidate
RP-HPLC, high-resolution intact-mass LC-MS (essential to distinguish variants), MS/MS sequence.
- ✓RP-HPLC purity
- ✓LC-MS/MS identity (modification confirmation)
- ✓Residual solvents
Common impurities & failure modes
- Wrong N-terminal modification
Plain vs. acetylated produces a 42 Da mass difference, easily resolved.
- Wrong C-terminus (free acid vs. amide)
1 Da mass difference; requires high-res MS.
- Sequence deletion at Pro-Gly-Pro
Proline coupling difficulty.