Orforglipron Testing
MW: ~760 g/mol
Small-molecule, oral GLP-1 receptor agonist in late-stage development.
What we test on Orforglipron
Small molecule — chiral HPLC and LC-MS/MS for impurity profile.
Standard GLP-1 / Metabolic Panel
- ✓RP-HPLC purity (UV 214 nm)
- ✓LC-MS/MS identity (Orbitrap)
- ✓Counter-ion / residual TFA
- ✓Water content (KF)
- ✓Endotoxin (LAL, USP <85>)
Common impurities in this category
Truncated sequences (des-Aib, des-His), deamidated isomers, free C18 diacid chain, oxidation products, and counter-ion variability (acetate vs. TFA).
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